I was prescribed flouricil for precancerous lesions on my lower lip. Here are my takes on what I did. Before you use the first application to buy children's toothpaste. I used bubble gum flavored. Anything with mint will send you into tears. Ask your doc for some lidocaine, 2% viscous solution. Two hours after applying the flouricil cream use the lidocaine. I found that just numbed my lip. Benzocaine burned terribly and created tears before it numbed. Wrap your pillow with a towel before bed and have a tube of aquaphor on the night stand. Use it liberally. I found that gold bond advanced healing ointment worked better at night. After you stop the flouricil be ready for some ugly looking lips for about a week so keep using the lidocaine and lip moisturizer as well as wrap your pillow.