Today's day 15 of Efudex treatment. Initially was told to apply for 1-2 wks or until "redness/crusting" occurred. Called doc asking if should continue treatment as have lots of bright red tenderness, but no "eroding". Nurse (or assistant?) said to extend treatment. I then mentioned the fatigue, headaches & diarrhea have been concerning. Nurse responded that none of that would be from using Efudex, because it's just a "topical cream". Not sure how to interpret this. My symptoms certainly seem associated with the treatment, but she was adamant that they couldn't be. While looking for answers I found your group. Has anyone else experienced similar symptoms? (By the way, thanks for being there. Been feeling kinda' lost & overwhelmed.....)