I understand your concern. I have had similar questions myself. I think you will find that the cream will absorb fairly quickly when you are applying a thin layer. Typically, my doctor doesn't suggest wrapping or bandaging the treated area.
To keep the cream from transferring, I suggest you apply it 30 minutes to an hour before you dress. As you continue to treat, you will likely notice that the cream absorbs more and more quickly.
I am including an article you might find helpful as you start treatment.
https://skincancer.net/life-with-skin-cancer/tips-for-efudex-users
Please know we are here for you! Reach out--we will be here!
April, SkinCancer.net, Moderator