I have had several instances of Bowen's disease but not for some time. In the past, they have been treated by freezing with liquid nitrogen (Cryotherapy) My dermatologist says that this is not popular any longer and has prescribed Efudex twice a day for 28 days. He warned that it can be quite aggressive and if it gets too bad, take a day or two to take a rest and start again. I am on day 10 and I have still had no reaction. Maybe the slightest tingling but no visual change. I am almost wondering if I have received a defective batch of cream. I will obviously persist. Is it normal to see no change after 10 days? I just wonder what others have experienced?