Hi Marg - I have done Efudex treatment over 6 times in the last 4 years. It is scary, but I can tell you that the results are amazing for pre-cancerous lesions. I am at the point now that I look forward to this treatment because I can actually see it working. As far as a cream to use for aftercare -I highly recommend Cicalfate Creme from Avene. It works wonders. Spread a nice thick coat of it on the area and leave overnight. Your skin will thank you!