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Chemotherapy kills or damages rapidly dividing cells. This means that chemotherapy is toxic to cancer cells, which divide rapidly and out of control. However, chemotherapy also affects rapidly dividing healthy cells. Examples include healthy blood cells, hair cells, and the mucous membranes that line the mouth, throat, and digestive system.1

Newer immunotherapies and targeted therapies are generally more effective than chemotherapy for treating melanoma.2 Their side effects may be less severe.2 Therefore, chemotherapy is not used as often now for skin cancer.2 Nevertheless, it may still be used to treat some skin cancers, especially if other drugs are not working.

Chemotherapy may be used alone or in combination with other treatments. Typical combinations are chemotherapy with immunotherapy or with radiation therapy. The US Food and Drug Administration has approved some chemotherapy drugs for certain cancers. However, when treating cancer, it is also common to use approved chemotherapy drugs “off-label,” which means for unapproved uses.3

How is chemotherapy given?

Systemic chemotherapy

Systemic (whole body) chemotherapy is often given by injection into a vein (intravenous), or under the skin (subcutaneously).2 It may also be taken by mouth in pill form. Systemic chemotherapy travels through out the body via the blood stream.1 Systemic chemotherapy can be used as a primary treatment to kill cancer cells that have spread to distant parts of the body (metastasized).

Systemic chemotherapy also is used as adjuvant therapy. Adjuvant therapy is an additional cancer treatment that is given after the primary (main) treatment. Adjuvant therapy can help lower the risk that the cancer comes back. Adjuvant systemic chemotherapy may be used after surgery to kill any remaining cancer cells.

Another use for systemic chemotherapy is treating cancer that cannot be removed with surgery.4 One example would be tumors that have grown around major nerves or blood vessels. Another example is cancer that is so widespread that it is not possible to remove all the tumors.

Isolated limb perfusion

When melanoma is only in the arm or leg, it may be possible just to treat that limb with chemotherapy.2

The limb is “isolated” from the rest of the body with a tourniquet. A tourniquet is a band or device that prevents blood flow in or out of the limb. The major blood vessels also are clamped.5 Tubes are inserted into the major artery and vein. Blood in the affected limb is routed through a machine. The machine heats the blood and infuses (puts) chemotherapy into it. Melphalan is a medication commonly used for this procedure.2,4 The medication circulates through the limb for 60 to 90 minutes. Before the doctor restores normal blood flow, the limb is cooled and remaining medication is flushed out.

This procedure allows the doctor to use high doses of chemotherapy that would cause severe side effects if given through the whole body.2 Up to 90% of people have a response to isolated limb perfusion.4 Complete response may be seen in as many as 58% of patients.4 However, this procedure is difficult to perform and is not offered everywhere. It is generally not appropriate for elderly or frail individuals.4

Intralesional therapy

Chemotherapy medication can be injected directly into a tumor. This is called intralesional administration. Intralesional chemotherapy is used to treat Kaposi sarcoma (KS).6 Vinblastine may be used for intralesional treatment of KS.

Topical chemotherapy

Fluorouracil is a topical chemotherapy medication. Topical means that the medication is applied to the skin. When fluorouracil is applied to the skin, it kills tumor cells on the skin surface.7 Fluorouracil is only used to treat actinic keratosis and thin basal cell carcinoma.

What types of skin cancer does chemotherapy treat?

Advanced melanoma. Chemotherapy is one option for treating advanced melanoma, for example:4

  • Treatment for widespread metastatic melanoma, if other medications are not working.
  • Primary treatment for metastatic melanoma confined to the arm or leg.
  • Adjuvant treatment for high-risk stage III melanoma after the lymph nodes and skin tumor have been removed with surgery.
  • Melanoma that has returned (recurred) and started to spread.

The chemotherapy drugs used to treat melanoma include:2,8

  • Dacarbazine (approved for melanoma)
  • Temozolomide
  • Nab-paclitaxel
  • Paclitaxel
  • Cisplatin
  • Carboplatin
  • Vinblastine

Outcomes after chemotherapy for melanoma have been disappointing. Fewer than 20% of patients with metastatic melanoma respond to chemotherapy.4

Chemotherapy may be used together with the cytokines interleukin-2 and interferon. This combination is called biochemotherapy. Biochemotherapy may work better than cytokines alone. When used as adjuvant therapy for stage III cancer, biochemotherapy doubled the recurrence-free survival time compared with interferon-alfa (4.0 years vs. 1.9 years).2 However, there was no difference in overall survival time between the two treatments.

Kaposi sarcoma

Chemotherapy weakens the immune system. Therefore, it can be challenging to use chemotherapy in patients with immune system problems, such as AIDS. Nevertheless, with careful treatment planning, chemotherapy may be used to treat Kaposi sarcoma (KS).9

Chemotherapy may be injected directly into tumors, such as those in the mouth.10 It may be used systemically if the cancer is widespread. The chemotherapy drugs used to treat KS include:

  • Liposomal doxorubicin (approved for KS)
  • Paclitaxel (approved for KS)
  • Vinblastine (approved for palliative treatment of KS)
  • Gemcitabine
  • Vinorelbine
  • Bleomycin
  • Vincristine
  • Etoposide

More than half of patients with KS improve if treated with chemotherapy.9 Between 46% and 59% of patients respond to liposomal doxorubicin.11 More than 70% of patients respond to paclitaxel. However, the KS does not go away completely.9 Within 6 to 7 months, most patients progress and need additional treatment.11

Merkel cell carcinoma

Systemic chemotherapy has been used to treat Merkel cell carcinoma (MCC). It shrinks or slows the spread of MCC tumors for a period of time. There also are reports of intralesional chemotherapy with bleomycin for early MCC.12 Because MCC is so rare, it has been hard to study chemotherapy. It is not clear how well it works and which patients have the best response.

No chemotherapy drugs have been approved specifically for MCC. However, drugs used to treat MCC include:12

  • Cisplatin
  • Carboplatin
  • Etoposide
  • Topotecan

Non-melanoma skin cancer

Squamous cell carcinoma (SCC) rarely spreads beyond the skin tumor. However, chemotherapy is one option for SCC that has spread.13 In this situation, chemotherapy may be combined with radiation therapy.13

Not much information is available about chemotherapy for advanced SCC or basal cell carcinoma. Chemotherapy medications that have been used for SCC include:7

  • Cisplatin
  • Doxorubicin
  • Fluorouracil
  • Capecitabine
  • Topotecan
  • Etoposide

What are the side effects of chemotherapy?

Systemic chemotherapy is usually given in cycles.1 You may need to stay in the hospital during treatment. This is done to manage side effects of the medications.

Systemic chemotherapy causes side effects throughout the body.1 Typical side effects of chemotherapy are:2,14

  • Hair loss
  • Mouth sores, taste changes, dry mouth
  • Loss of appetite
  • Nausea and vomiting
  • Diarrhea or constipation
  • Infection
  • Bleeding problems and easy bruising
  • Anemia and fatigue
  • Memory changes
  • Nerve changes, including numbness, tingling, burning, or weakness
  • Pain
  • Fluid retention and swelling
  • Changes in sexual function and fertility

Many side effects can be prevented or managed. For example, blood transfusions can correct low blood cell levels.1 You can take drugs for nausea and vomiting. You may also take antibiotics and antifungals to prevent infection. Side effects vary among specific chemotherapy drugs and your provider will manage them accordingly.

Some people try complementary medicine to relieve chemotherapy side effects.15 You may find that meditation or hypnosis reduces stress during procedures or treatment. However, it is important to discuss any complementary medicine you are considering with your doctor. Herbal medicine, vitamins, minerals, and other supplements can interact with your medications. They may reduce the effect of the medication. The interaction could lead to unsafe side effects.

Written by: Sarah O'Brien | Last reviewed: December 2019.
  1. PubMed Health. How does chemotherapy work? Accessed April 19, 2017
  2. American Cancer Society. Melanoma skin cancer. Accessed January 5, 2017 at:
  3. American Cancer Society. Off-label drug use. Accessed April 19, 2017 at:
  4. NCCN Clinical Practice Guidelines in Oncology. Melanoma. Version 1.2017. Published November 10, 2016.
  5. Wu B. Isolated limb perfusion for advanced melanoma. DermNet NZ. Accessed April 19, 2017 at:
  6. American Cancer Society. Local therapy for Kaposi Sarcoma. Accessed April 19, 2017 at:
  7. American Cancer Society. Basal and squamous cell skin cancers. Accessed January 5, 2017 at:
  8. National Cancer Institute. Drugs approved for melanoma. Accessed April 19, 2017 at:
  9. American Cancer Society. Chemotherapy for Kaposi sarcoma. Accessed April 19, 2017 at:
  10. National Cancer Institute. Drugs approved for Kaposi Sarcoma. Accessed April 19, 2017 at:
  11. Sullivan RJ, Pantanowitz L, Dezube BJ. Targeted therapy for Kaposi sarcoma. BioDrugs. 2009;23:69-75.
  12. American Cancer Society. Chemotherapy for Merkel cell carcinoma. Accessed April 19, 2017 at:
  13. NCCN Clinical Practice Guidelines in Oncology. Squamous cell skin cancer. Version 1.2017. Published October 3, 2016.
  14. National Cancer Institute. Chemotherapy side effects series. Accessed April 19, 2017 at:
  15. Ernst E. Patient education: Complementary and alternative medicine treatments (CAM) for cancer (Beyond the Basics). UpToDate. Accessed April 19, 2017 at: