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Has anyone treated the lip area with Efudex?

I have treated my chest and face with Efudex, but I haven't treated my lips. I'm looking for any pointers on how to best go about avoiding ingesting the cream and any tips for staying comfortable while treating this highly sensitive area. Thanks in advance!

  1. Hi April, I have needed to use 5FU on my lips, medication that is similar to Efudex.
    You are right that the lips are very sensitive.
    Due to that reason, I was unable to use the cream for as long as I have used it on other facial areas.
    I used the cream at bedtime to avoid licking my lips.
    When I applied the cream too close to my inner lips, to remove any excess, I would use a gloved finger, (covered with a gauze pad), in my mouth and then withdraw it through pursed lips.
    If painful, I would use cool compresses as needed.
    Despite the shorter time used, the 5FU was quite effective, thank heavens!
    I wish you the very best of luck, even better than my experience!
    Please keep me in the loop on how you are doing.
    Thanks, Elizabeth Lebowitz - SkinCancer.net - Site Moderator

    1. Thank you so much for your advice. I feel like I'm an old pro with Efudex, but this lip treatment has thrown me for a loop. I've had a few spots frozen on my lips over the years, and strangely enough, I assumed I was clear in the lip area. I knew better--it's never-ending. I'm definitely taking note of your methods. I plan to start mid-April and finish up before summer break begins. Thanks again! April, Skincancer.net, Moderator

      1. I had Mohs on my lower lip about four years ago. Took a big chunk out and stitched it up after. I have been getting my lip frozen every 6 months since. However, I just had to go twice the past two months. I’m wondering if it is another spot that needs to be biopsied. I do not want to have a biopsy out of my lip again. It was a huge hole then cotterized (sp) after. Had the Mohs shortly after. How would he fix a bigger hole in my lip if it is cancerous again, and will the lip heal fully if she biopsies it and it isn’t cancerous? Thanks!

        1. Hi Jimmy,
          I'm so sorry you're facing these issues once again. I know you have a million questions and are expecting the worst. It sounds like you have done everything right by following up with regular visits. Hopefully, the spot you're concerned about is not one that needs the dreaded biopsy. I wish I had the answer to your question about how completely you would heal following the procedure. Unfortunately, I don't have personal experience with a second surgery in the same area. I'm going to share your question with the team and ask that it be posted on our Facebook page to see if we can find members who can ease your fears. I'm keeping you in my thoughts! April, @skincancer.net, Moderator

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